![]() ![]() 12 Lower hepatic expression of MTP plays a crucial role in NAFLD development. Microsomal triglyceride transfer protein (MTP, or MTTP), a lipid transfer protein involved in apolipoprotein B (apoB) assembly, is localized to the endoplasmic reticulum in hepatocytes and enterocytes. 7 Previous studies suggested that genetic factors play an important role in NAFLD etiology by altering hepatic lipid metabolism. In general, NAFLD is a multifactorial disease produced by complex interactions between nutritional factors, lifestyle choices, and genetic determinants. 5 Therefore, the possibility of NAFLD increases proportionately with the number of metabolic syndrome factors present. 4 Epidemiologic studies support belief to the relation between NAFLD and MS, the latter may be the etiologic agent that triggers the pathophysiological cascade of NAFLD. Non-alcoholic fatty liver disease is no longer considered to be a primary liver disease, but rather a constituent of metabolic syndrome. 1 Numerous risk factors have been suggested in NAFLD pathogenesis, including advanced age, dietary habits, obesity, and some traits of metabolic syndrome (MS), such as insulin resistance and dyslipidemia. Non-alcoholic fatty liver disease (NAFLD) is a universal disorder which is considered as the most common liver disease worldwide it is defined as the accumulation of excessive fat in the liver in the absence of excessive drinking of alcohol and any secondary cause. ![]()
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